Illustration from Scientific Research

Cl-binding to E6/R8 pairs in wild-type HsLRRC8A in a representative snapshot of MD trajectories (left) and its schematic representation (right). In an asymmetric unit, the side chain of E6 in one subunit and the side chain of R8 or T5 in the neighboring subunit form H-bonds. Cl-is depicted by red spheres. H-bonds are shown as red dashed lines.

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