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WT and Slc38a5−/− BMDCs were treated with 5 μg/mL IMQ in the presence or absence of concanamycin B (ConB; 10 ng/mL) for 24 h, and then the secretion of IL-1β, IL-23p19, tumor necrosis factor α (TNF-α), and IL-6 cytokines in supernatant was detected by ELISA. Data are means ± SD. Data represent one of at least two independent experiments with consistent results. A two-tailed, unpaired Student’s t test (I–L), a one-way ANOVA with Sidak’s multiple comparisons test (C), or a two-way ANOVA with Tukey’s multiple comparisons test (A and E) was used to determine statistical significance (n.s., no significant difference,∗p < 0.05,∗∗p < 0.01,∗∗∗p < 0.001).

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