Protein Structure from Scientific Research

Predicted structural change induced by the G580C substitution. The substitution of a glycine (green) with a bulkier amino acid (cysteine, orange) changes the RSA of the amino acid at position 580 (5.9%3.7%). Although the substitution introduces an amino acid with a free SH group that can make disulphide bonds with other amino acids with free SH groups (depicted as yellow spheres), the distance between C580 and the closer amino acid with a free SH group (C486, 10.519 A) is too big to allow the making of such type of bond.

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