Protein Structure from Scientific Research

Predicted structural change induced by the D459E substitution. The OD2 atom of Asp459 is predicted to form a buried salt bridge with NZ atom of Lys460 (K460). The substitution of an aspartic acid with a glutamic acid at position 459 increases the distance between the NZ atom of Lys460 and the closer oxygen atom (OE2) available to make a salt bridge, breaking this bond.

DOI