Line Plot from Scientific Research

Phosphoinositide gradients: PIP3 is strongly graded with its peak toward the center of the domain, whereas PTEN (n = 6), which breaks PIP3 down, is excluded from PIP3 domains. PI4,5P2 (n = 7), the substrate for PIP3 production, shows an outside-in gradient. This is consistent with PIP3 being produced within PIP3 domains and diffusing out for destruction by PTEN; whereas PI4,5P is depleted within the domain by PIP3 formation and replenished by diffusion from outside. PI4P (n = 7) shows little variation.

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