The estimated OR for ET and PV across five significantly associated hematological trait PGSs, PGS CH , PGS MPN-46/1 and PGS MPN-other in the MPN patient cohort (red; ET, n = 581; PV, n = 112; control, n = 30,305) and the UKBB-MPN cohort (gray; ET, n = 156; PV, n = 161; control, n = 161,872). ORs were estimated in a multinomial logistic regression model. Data are presented as the OR (change in odds per increase of 1 s.d. in PGS; solid dots) with 95% CI (error bars). An asterisk indicates significant germline PGSs ( P < 0.05 in both cohorts). The corresponding ORs and P values are shown in Supplementary Table 15 . Age, sex and ten PCs were fit as covariates for both datasets. The VAF of JAK2 V617F and the sample batch were two additional covariates included for the UKBB-MPN cohort.
