Plots showing the estimated hematological trait variation (%; bars) with 1 s.e. (error bars) explained by the variables in e. The percentage variation shown for a variable was estimated conditional on the remaining variables in a selected model with the s.e. estimated via bootstrapping ( Methods ). Blood trait phenotype data were available for n = 268–281 individuals in the UKBB-MPN cohort (varied across traits). For a specific trait, a variable has a blank result if it did not pass the significance threshold ( P = 0.0011 for the MPN patient cohort and 0.0063 for the UKBB-MPN cohort, Bonferroni corrected; Methods ). JAK2 includes V617F and exon 12 mutation in the MPN patient cohort and V617F only in the UKBB-MPN cohort; CALR , exon 9 frameshift (+1 bp) mutation.
