Average synaptosome diameter. The analyses were conducted by using data from 124, 94, and 300 synaptosomes harvested from human postmortem orbitofrontal cortex samples from Parkinson’s disease, Alzheimer’s disease brains, and control samples, respectively and analyzed by linear mixed effects models and 95% confidence intervals. For aSyn, aggregate length, area, and eccentricity, as well as synaptosome radius show significant differences as the synaptic aggregates are longer, larger, and more fibrillar than the extra-synaptic ones. Synaptosomes from PD brains also have a greater diameter than the ones from the control brain. For AB, aggregate length and area, as well as synaptosome radius show significant differences as the synaptic aggregates are longer and larger. For AT8-positive tau, both synaptic and extra-synaptic aggregate count is significantly higher in the AD brains compared to the controls. Synaptosomes from AD brains also have a greater diameter than the ones from the control brains.
