Protein Structure from Scientific Research

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Conformational changes in the fingers and thumb subdomains. The fingers and thumb subdomains of EC (left) and PC (middle) are displayed as ribbon models. EC and PC are superimposed in the right panel, where the fingers and thumb subdomains of EC are not shown, and the rectangle indicates the putative reaction chamber required forde novoRNA synthesis initiation. In EC (left), helices (H18, H19, H34, and H35) and their intervening loops are colored light salmon and medium spring green, respectively. The helices within the arch (Dodger blue) are colored medium slate blue. The priming loop, H36, and H37 are colored according to Figure 1A. These coloring rules are also applied to PC (middle).
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