Workflow from Scientific Research

When a hydrophobic signal sequence (or transmembrane domain) is translated, the signal recognition particle (SRP) is recruited to the ribosome. This leads to targeting of the ribosome-nascent chain complex with the associated mRNA to the ER (or plasma membrane in prokaryotes) via an interaction between SRP and the SRP receptor. The ribosome docks on a translocon centered around Sec61 (or SecY in prokaryotes), thereby localizing the mRNA.

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