Illustration from Scientific Research

A hypothetical model of BRCA2 sliding on dsDNA via individual DNA-binding modules with different sliding rates and DNA affinities. A mixed mode of movement, where hopping has a contribution, is also possible. (A–D) For simplicity, BRCA2 is shown as a dimer. However, BRCA2 could engage in the proposed sliding mechanisms in monomeric form or as a heterogeneous oligomer.

DOI