Protein Structure from Scientific Research

Snapshots from CG simulations of SPNS2 in a PI(4,5)P2containing phospholipid bilayer (back-mapped to atomistic resolution). Starting from the initial state, Arg43 or the arginine patch (Arg 23-28) interacts with PI(4,5)P2molecule, and the N terminus guides the PI(4,5)P2molecule closer to SPNS2. SPNS2 is shown in blue (with the N terminus colored in yellow), phospholipids are shown on a white surface (with the phosphates shown as gray spheres), and PI(4,5)P2is shown as orange sticks.

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