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The formation of embryos and embryo models using methods that bypass fertilization makes the consideration of developmental potential necessary for a refined definition. Because potential, as manifested in a fetus, is the result of a combination of intrinsic cellular potential and extrinsic support, we propose that cells capable of forming all the cells of the body (referred to as pluripotent stem cells for the period between 7 and 14 d.p.f.) should be considered differently when they are isolated versus when they are in a supportive environment fulfilling, at least, extraembryonic and uterine functions.

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