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Summary of evolution campaigns for whole PE2 phage in the v1 (yellow), v2 (blue), and v3 (purple) circuits. Green shading indicates reversion analysis. PANCE passages (p) or hours of PACE (h) are in parentheses. Arrowheads indicate increases in selection stringency. Mutants characterized in mammalian cells are denoted with a dot and labeled. Additional increases in stringency are in pink.

DOI