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Diagram illustrating the domain structure of human HERC2 (4,834 amino acids) and overlapping HERC2 fragments tested for interaction with ZNRD2 inFigure S4G. HERC2 contains three RCC1-like domains (RLD1–3) and a C-terminal HECT E3 ligase catalytic domain (HECT). The HERC2 fragment containing RLD3 (F5; highlighted in red) interacts with ZNRD2 (seeFigure S4G).
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