Protein Structure from Scientific Research

The crystal structure spanning residues 118–261 of human TMEM106B, shown as cartoons, colored by the rainbow gradient from N (blue) to C (red) terminus. The remainder of the protein, comprising the transmembrane region (TM, residues 97–117) and cytoplasmic tail (residues 1–96), is schematically represented as thick gray lines. Secondary structure elements (α1, β1–β7), N-acetylglucosamine (NAG) residues, Cys214–Cys253 disulfide, the TM, and the cytoplasmic tail are indicated. NAG residues are shown as sticks with carbon atoms in gray.

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