Summary of responses obtained from PIEZO2-deficient individuals to GI-PROMIS questionnaires. Data indicate the subject identifier, age at which the questionnaires were answered and gender. Data are organized by ascending age (top set of rows) and symptoms are categorized in sensory deficits and GI problems, which span constipation and diarrhea. Each question assessed symptoms from the 7 days prior to the survey. Unless otherwise noted, the color code illustrates the following: gray represents the average response from 1,177 healthy control participants, which indicates no pathology and is typically close to never experience or lacking the particular symptom in the past 7 days; blue: rarely; yellow: sometimes; orange: often, red: always. Therefore, every color except for gray indicates a deviation from the average. Blank indicates unanswered questions. Individual identifier corresponds to those published in our previous urinary function study.25The symbol * denotes those subjects who experienced neonatal and childhood constipation, + indicates lack of medical history concerning their GI behaviors in childhood. NA, not answered; No path, no pathology.
