Scatter Plot from Scientific Research

Neutralization profiles of the 3d-BA.4/5-HCPs against pseudoviruses bearing BA.4/5-XBB chimeric spikes. The antibody data against XBB, BA.4/5, and BA.4/5 bearing F490S, N460K, D339H, R346T, and V445P were the same as panel b . For panels g and f , data were plotted as the geometric mean with a 95% confidence interval. Mutations with sequence numbers < 10 from May to October 2022 were not fitted. In the correlation analysis of R 2 with nAb titers, R 2 for mutations with a decreasing trend ( k < 0) in the time frame was assigned as 0. P values in panel b were calculated using two-tailed Wilcoxon signed-rank tests of paired samples; P values in panel d – f were the result of a two-tailed test for the Spearman rank correlation coefficient. * P < 0.05. ** P < 0.01. *** P < 0.001. **** P < 0.0001. ns not significant, nAb neutralizing antibody, ID 50 half-maximal inhibitory dilution.

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