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Sample preference of each cluster estimated by the RO/E index; ++ (2 ≤ RO/E < 3, P < 0.05) represents enriched; + (1.2 ≤ RO/E < 2, P < 0.05) represents slightly enriched; +/− (0.8 ≤ RO/E < 1.2 or P > 0.05) represents non-significant; and − (0 < RO/E < 0.8, P < 0.05) represents deletion.
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