Scatter Plot from Scientific Research

An antigenic map by ref. 25 served as the base map for all antibody landscapes. Virus variants are shown as color-filled circles. Variants with additional substitutions from their root variant are shown as smaller circles. Variants associated with significant outbreaks or pandemic waves are secondarily encircled in red. Individual sera from individuals who were infected are displayed as open squares in the color of their root variant or gray for mRNA-1273 vaccinated sera; small dark squares represent clinical trial participants. One grid unit in the map corresponds to a twofold dilution in the neutralization assay. Within the x and y axes, the map orientation is free as antigenic distances are relative. Small triangles point to sera outside the shown map area.

DOI