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Comparison between three versions of ESM1b-based effect scores, CADD (a supervised VEP method) and three baseline models as classifiers of pathogenic versus benign in-frame indels (over the same set of variants as in a ). One-tailed P values are shown for the differences between the performance of CADD and the ESM1b-based effect scores ( Methods ). Right: partitioning of the 3,470 in-frame indels into deletions, insertions and deletioninsertion combinations (delins).
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