Bar Plot from Scientific Research

Assessment of ESM1b and three baseline models as classifiers of pathogenic versus benign stop-gain variants, over variants expected to either (1) not undergo NMD (3,672 pathogenic and 147 benign variants), (2) undergo NMD (32,362 pathogenic and 198 benign variants) or (3) all stop-gain variants (36,034 pathogenic and 345 benign variants). Error bars correspond to s.d. of the ROC-AUC scores centered around the mean (estimated by bootstrapping).

DOI