Bar Plot from Scientific Research

Evaluation of 43 VEP methods (including ESM1b and EVE) on a DMS benchmark containing 28 assays over 15 different human genes (Supplementary Table 1). Of the entire set of 76,133 variants in 15 genes, 16,049 variants in 11 genes obtained effect scores by all 43 VEP methods. We excluded 3 VEP methods, VARITY_ER, VARITY_R and MTBAN (Methods), which would have dramatically reduced the number of variants and genes shared by all methods. The methods are sorted by the average Spearman’s correlation between each method’s scores and the experimental scores.

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