Prime editing efficiency in bulk or GFP-positive population from the brain cortex collected 3 weeks following P0 ICV injection targeting the Dnmt1 locus with v3 PE3-eVLPs and v3b PE3-eVLPs. Bars represent the average prime editing efficiency of three mice and error bars represent the standard deviation, with each dot representing an individual mouse. Each mouse received approximately 1.0 x 10 11 eVLPs in total.