Table Image from Scientific Research

The alleles observed at a de novo SNV site are statistically phased together with adjacent germline alleles to calculate an LD refinement score that estimates the percentage of cells in which the alleles do not cosegregate with neighboring germline alleles. De novo SNVs with high LD refinement scores are classified as the putative somatic SNVs, and their genotypes at the single cell/cluster level are inferred using Monovar.

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