Bar Plot from Scientific Research

Change in gene expression after perturbing the combination PTPN12 and ZBTB25. The gray bars show the true mean postperturbation gene expression change (n = 257). The hatched gray bars show the true change for each of the two single-gene perturbations performed individually (PTPN12 n = 164 and ZBTB25 n = 247), which are summed by the naive additive model. The red bar indicates the prediction made by GEARS (n = 3 trained models). Error bars correspond to 95% confidence interval.

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