Upper : Mean log-fold change in gene expression in SEM cells following 96 h MLL-AF4 knockdown for genes associated with an MLL-AF4-bound enhancer or genes associated with an enhancer not bound by MLL-AF4, n = 3 independent experiments. Statistical significance calculated using a two-sided Mann–Whitney U test, p = 2.96 x 10 -21 . Midline shows median, with upper and lower hinges showing the 25th and 75th percentile, respectively. Upper and lower hinges extend to the largest and smallest datapoints within 1.5 times the interquartile range of either hinge. Lower : Proportion of enhancers associated with genes displaying each transcriptional response to MLL-AF4 knockdown.
