Workflow from Scientific Research

Schematic defining origins of Organoid and Tissue TNF gene signatures (left column) as well as Organoid TNF score (bottom middle column) used in this manuscript, with special attention to FSGS/MCD cohort with the NEPTUNE study (bottom left column) demonstrating poorer outcomes and higher TNF activity for individuals in cluster 3 as in Mariani et al. (2023); right column shows strategy for identifying potential biomarker candidates using Organoid TNF signature genes. a, c created using BioRender. Source data are provided as a Source Data file.

DOI