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A scheme illustrating the underlying concept of this study. True A-to-I RNA editing events revealed by A-to-G substitutions during RNA sequencing have to be separated from other A-to-G sequence changes that are unrelated to ADAR editing. This work is based on extensive independent validation by Sanger sequencing as to key component to test every indicated step of the analytical pipeline in order to provide an authentic compendium of true ADAR editing events in a particular biological system

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