Bar graph of biotinylation levels of CIAR-PM-293 cells, which were transfected with Ras-LOCKR-PL candidates, and 500 M biotin was added for 16 h without (-stimulation) or with (+stimulation) 250 nM A115 ( n = 4 experiments per condition). Ratio is +stimulation divided by -stimulation. The numbers shown over the bar graphs represent the number of key:cage weakening mutations.
