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Experimental procedure of cross-sectional study. Two independent multi-center cohorts were included in the global metabolomic/lipidomic analyses. Multivariate statistical analysis was used to discover and validate the specific metabolite patterns of HoFH. Regression analysis was employed to investigate the associations of HoFH-related metabolites with typical clinical phenotypes of HoFH patients.
#Workflow#PCA#Network#Cross-sectional Study#Metabolomic Analysis#Lipidomic Analysis#Multivariate Statistical Analysis#HoFH#Regression Analysis#Clinical Phenotypes
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