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Amount of testosterone in the supernatants of fetal human testis explants of 8–10 (gray line) or 10–12 (black line) DW cultured for 72 h in presence of controls (DMSO and/or EtOH) or 10 −7 to 10 −5 M of (A) CDB, (B) THC, or (C) a mixture of CBD/THC (ratio 1:1). Results are expressed related to the amount of testosterone produced during the first 24 h of culture (D0) and as fold from the respective control. Data are means +/− SEM. An ANOVA test was performed followed by Friedman test for pair comparisons (*, p < 0.05; ***, p < 0.01; ** p < 0.001; ****, p < 0.0001).
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