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Pairwise comparisons of HFD-altered bacterial taxa are shown, with a color gradient indicating Pearson’s correlation coefficients. HFD-altered serum metabolites (blue: HFD-enriched serum metabolites; green: serum metabolites downregulated in HFD-fed mice) were related to each bacterial taxon by Mantel tests. Edge width corresponds to Mantel’s r statistic for the corresponding distance correlations, and edge color indicates the statistical significance based on 999 permutations.
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