Heatmap from Scientific Research

Unsupervised clustering of genomic features. HRD cluster: classification of tumors harboring higher (HRD-H) or lower (HRD-L) level of HRD genomic scar features. S2 and S13 (APOBEC): mutation signatures 2 and 13 linked to APOBEC enzyme activity. S3 (HRD): mutation signature linked to homologous recombination deficiency. CYT score: cytolytic activity score calculated from mRNA expression levels of GZMA and PRF1. CIN, chromosome instability; TAI, telomeraic allelic imbalance; LOH, loss-of-heterozygosity; LST, large-scale transitions. Subtype: PAM50 subtype classification.

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