Investigation of the overlap of DEPs in brains of 5xFAD mice and postmortem AD patients. Protein changes in cortical and hippocampal tissues of 8- and 5-month-old mice (DE.cortex.Age8; DE.hippo.Age5; DE.hippo.Age8) that contain A aggregates (Fig. 1 d) were compared with patient protein measurements. The amounts of DEPs are denoted analogously to Fig. 2 a or have been abbreviated (C8, H5, H8). The human AD data were obtained from Drummond 2022 (D22, [ 43 ]), Johnson 2020 (J20, [ 41 ]), and Johnson 2022 (J22, [ 42 ]). The total numbers of DEPs in each dataset are indicated in brackets. In DE.cortex.Age8 and DE.hippo.Age5, the proteins present in all four data sets are depicted with gene names.
