Example Spearman correlations and concordance representations of dysregulated proteins from 5xFAD mice (DE.cortex.Age8, DE.hippo.Age5, and DE.hippo.Age8) versus human AD patient data from Drummond 2022 along with human AD data against each other (D22 vs J22, D22 vs J20, J20 vs J22) are shown. The identifiers are denoted analogously to Figs. 2 a and 4 a. Proteins concordantly up- or downregulated in 5xFAD mice and human AD patient brains are shown in gray quadrants and marked in blue. Proteins of interest with highly significant fold-changes are indicated with gene names. Correlating but non-concordant proteins are marked in brown.
