Numbers of proteins significantly differentially regulated. A2TC (Age 2, Tissue Cortex), A5TC and A8TC label the numbers of proteins for which the transgene effect is significant in cortex, at 2, 5, and 8 months, respectively. Proteins more abundant in 5xFAD mice are shown in red, while proteins more abundant in wild-type mice are shown in blue. A2TH (Age 2, Tissue Hippocampus), A5TH, and A8TH label the same comparison in hippocampus. A52TC (Age 5 vs 2, Tissue Cortex), A85TC and A82TC refer to the numbers of proteins for which the transgene effect is significantly different at two time points (5 vs 2, 8 vs 5, and 8 vs 2 months) in cortex. The numbers of proteins which increase in abundance with age are shown in red, while the numbers of proteins that decrease with age are shown in blue. The corresponding labelling for the hippocampus samples are A52TH (Age 5 vs 2, Tissue Hippocampus), A85TH and A82TH. Finally, A2THC (Age 2, Tissue Hippocampus vs Cortex), A5THC and A8THC report the numbers of proteins for which the transgene effect is significantly different in cortex and hippocampus at 2, 5, and 8 months, respectively. Higher hippocampus abundance is shown in red on the right, and higher cortex abundance in blue on the left. The underlying data are available as Additional file 3 : Supplementary Excel File 1c.
