For a given threshold x , safety coverage of the sequences whose stable structure retention is at least x (on the left), and the proportion of the sequences whose stable structure retention is at least x (on the right). The results are split into different identity ranges. Restricted to sequences whose safety coverage is at most 80%. the purple curves, which cover sequences from the identity range 40–70%, show in b that 10% out of the sequences with at most 80% safety coverage inside this identity range (right plot) have a stable structure retention of 100% and only a safety coverage of around 5% (left plot)
