Table Image from Scientific Research

Results of the in vivo radiant heat tail flick assay in mice comparing the effect of single isomers: The antinociceptive effect of test compounds was assessed 20, 30, 60 and 120 min after s.c. administration at various doses (see the Supporting Information for details). The antinociceptive potencies (ED50) were calculated from linear dose response curves. The ED50 values and 84 % confidence intervals were calculated at the most effective time point, namely, 20 min after s.c. administration.

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