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Three-agent synthetic consortium designed to exhibit a netosis-like response. Responsive DNA-based particles detect model targets (E. coli) by sensing medium acidification induced by the glucose metabolism of the cells. Activated particles respond by forming a sticky DNAcholesterol network that immobilizes the bacteria and, at the same time, permeabilizes antibiotic-loaded giant unilamellar vesicles (GUVs). Antibiotic release suppresses bacterial growth and division, fulfilling the antimicrobial role of the DNA-binding proteins in the biological system.

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