The Euclidean distance between the newly added control mice and previously identified groups in behavioral feature space(control vs. HP: 5.5 ± 1.2 vs. 7.9 ± 0.8 [t = −5.18931, p = 8.232351e-05]; control vs. mEC: 5.5 ± 1.2 vs. 10.8 ± 0.9 [t = −10.75881, p = 5.729525e-09]; control vs. AppNL-G-F: 5.5 ± 1.2 vs. 7.0 ± 0.8 [t = −3.20276, p = 4.932517e-03]; control vs. undef.: 5.5 ± 1.2 vs. 13.4 ± 1.1 [t = −15.21472, p = 4.063801e-11]). All data are represented as mean ± standard error of the mean (SEM). Independent-samples Student’s t test was used for all comparisons, unless stated otherwise. The normality of the data was verified with a Shapiro-Wilk test, and p values adjusted for false discovery rate with Benjamini-Hochberg correction. *p < 0.05, **p < 0.01, ***p < 0.005; n.s., not significant. See also Figures S3 and S9 and Table S2.
