PSVT=paroxysmal supraventricular tachycardia. *Patients received two doses of 70 mg etripamil as a test dose. The 706 patients include 48 who were previously enrolled in NODE-301 part 1 and did not have a PSVT event or use study medication in that trial; these patients were re-randomised for the RAPID trial after tolerating the test dose. Also included are 34 patients from NODE-301 part 1 whose masked data were carried forward and analysed in RAPID datasets; these patients received one 70 mg dose of etripamil as a test dose during NODE-301 part 1 and did not have a paroxysmal supraventricular tachycardia episode by the cut-off date (Jan 15, 2020) of that study. †Includes 658 patients randomised to a placebo or an etripamil optional-repeat-dose regimen and 34 patients randomised to a placebo or etripamil single-dose regimen from the NODE-301 part 1 study. ‡July 20, 2022. §For patients on the optional-repeat-dose regimen, a second dose was administered if symptoms persisted after 10 min. ¶The efficacy population excluded patients who took the study drug after PSVT conversion or during an episode that was adjudicated as non-atrioventricular-nodal-dependent PSVT (eg, atrial flutter or sinus tachycardia), or if substantial electrocardiogram signal loss occurred.
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