Illustration from Scientific Research

Sequence alignment showing amino acid residues of wild-type (HsTFE-α, anEcTFE-α, and EcTFE-α) and the mutated variants in the A5-H7 loop and in the H8 helical region of HsTFE-α. Residues L225-T236 are deleted in variant 1 (highlighted in yellow) and residues K249-R279 of HsTFE-α are replaced by residues K203-R225 of anEcTFE-α in variant 2 (highlighted in magenta). The mutated residues in variants 3 and 4 are highlighted in red. Every tenth residue of HsTFE-α is numbered at the top of the alignment.

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