Line Plot from Scientific Research

Predicted coverage of potentially ligandable cysteines (y axis) at given overall cysteine coverage (lines), versus selectivity of labeling toward ligandable cysteines (x axis). Selectivity represents the fraction of liganded Cys identified in each study compared to the fraction of liganded Cys identified in combined fragment screening datasets (16.2%); the total number of ligandable Cys is estimated by extending the fraction of ligandable Cys (16.2%) to all 261,260 Cys in the human proteome.

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