Illustration from Scientific Research

A schematic showing how clonality types of the de novo chromatin contacts are determined. Hi-C reads harboring a variant with known clonality type (green square: clonal and red square: subclonal) spanning the de novo chromatin contacts (light blue reads) are highlighted in translucent yellow (top panel). A genome track example shows de novo chromatin contacts found in patient P35 tumor chromosome 8. Translucent green and green bars show mapped variants supporting the clonality type of the Hi-C interactions consisting of the de novo chromatin contacts (bottom panel).

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