Heatmap from Scientific Research

Top panel: a normalized Hi-C contact map of P35’s tumor showing a representative example of adjacent TAD-boundary-exceeding SE-hijacking at chromosome 22 (chr22):22,419–30,268 kb (40 kb resolution) as well as genome browser tracks of pan-normal TAD, RNA-seq, pan-normal SEs, and WGS-based SVs. Bottom panel: a reorganized Hi-C contact map showing multi-TAD-spanning de novo chromatin contacts. Fused domains are marked with dashed line triangles (canonical model: blue, extended model: green). Translucent blue and orange marks show SE and CCDC117 promoter locations, respectively. The SE-promoter rewired interaction is marked with red and blue solid lines and light green dot.

DOI