A boxplot showing the effects of newly established SE-promoter interactions on gene expression (dark orange, n = 1,695, log2 fold changes compared with the matched adjacent normal tissue). The dark gray box indicates the SE-promoter pairs without significant interactions (n = 1,311). The light gray box represents promoters involved in the de novo chromatin contacts but not associated with relocated SEs (n = 2,095). The dark blue box indicates promoters in the de novo chromatin contacts without SEs (n = 1,469). Statistical differences between the two groups were calculated by performing two-sided Kolmogorov-Smirnov (KS) tests (*p < 0.001, and NS, not significant).
