Boxplots showing the effects of newly established SE-promoter interactions on gene expression (log2 fold changes compared with the matched adjacent normal tissue) based on CNs. Box colors indicate SE-promoter combination cases. Genes with fragmented CNs were not included. Statistical differences between the two groups were calculated by performing two-sided KS tests (*p < 0.05, ***p < 0.001, and NS, not significant). For boxplots, the box represents the interquartile range (IQR), and the whiskers correspond to the highest and lowest points within 1.5 IQR. See also Figure S4 and Tables S4 and S5.