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Serum cytokines were measured on day 10 after CpG treatment. Data in (A) are mean with SEM pooled from three individual experiments. n = 7 (WT, PBS), n = 5 (F121A, PBS), n = 16 (WT, CpG), and n = 17 (F121A, CpG) mice. Data in (C)–(F) are mean with SEM representative of three individual experiments. n = 3 (WT, PBS), n = 3 (F121A, PBS), n = 6 (WT, CpG), and n = 6 (F121A, CpG) mice. Individual symbols represent one mouse. Unpaired t tests were used in (A), (C), and (E). One-way ANOVA was used in (D) and (F). ns, not significant;*p < 0.05;**p < 0.01;***p < 0.001. See alsoFigures S1andS2.
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