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Enrichment of DN1 and DN3 among genes downregulated by sugar in a CWO-dependent manner. RNA-seq of larvae of the control (ctrl;w1118) andcwoB9genotypes exposed for 8 h to an LSD or an HSD, respectively (n = 4; 10 larvae/sample; LSD = 10% yeast; HSD = 10% yeast + 15% sucrose). RNA-seq identifiedcwo-dependent and sugar-regulated genes (adj.p.value < 0.05). These genes were overlapped with the previously identified 14 clusters revealing a significant overlap with clusters DN1 (64%, adj.p.value = 9.1e-89) and DN3 (71%, adj.p.value = 1.2e-128).

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